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50μL/100μL

Catalog No :AR1000

Reactivity : Human;

Applications : WB;IHC;IF;IP;ELISA

Target : PMS2

Fields : >>Mismatch repair;>>Fanconi anemia pathway

Gene Name : PMS2 PMSL2

Protein Name : Postmeiotic Segregation Increased 2(PMS2) Human

Gene Id : 5395

Human Swiss Prot No : P54278

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : IHC 1:200-1000,WB 1:500-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : --20°C

Molecularweight : 96kD

Observed Band : 110kD

The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination.This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome

應(yīng)用： WB;IHC;IF;IP;ELISA
稀釋比例： IHC 1:200-1000,WB 1:500-5000,IF 1:200-1000,ELISA 1:5000-20000,IP
1:50-200

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