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50μL/100μL

Catalog No : AR1001

Reactivity : Mouse; Rat

Applications : WB;IHC;IF;IP;ELISA

Target : MMP-9

Fields : >>Endocrine resistance;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Leukocyte transendothelial migration;>>Estrogen signaling pathway;>>Relaxin signaling pathway;>>Hepatitis B;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Prostate cancer;>>Bladder cancer;>>Diabetic cardiomyopathy;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis

Gene Name : MMP9 CLG4B

Protein Name : MMP9 (Cleaved-Met94) Human

Gene Id : 4318

Human Swiss Prot No : P14780 Mouse

Gene Id : 17395

Mouse Swiss Prot No : P41245

Rat Gene Id : 81687

Rat Swiss Prot No : P50282

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : IHC 1:200-1000,WB 1:500-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : -20°C

Predicted band size: 78kDa

Observed band size: 80-92kDa

catalytic activity:Cleavage of gelatin types I and V and collagen types IV and V.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.,domain:The conserved cysteine present in the cysteineswitch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5).,function:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter Nterminal one quarter fragments. Degrades fibronectin but not laminin or Pzpeptide.,induction:Activated by 4-aminophenylmercuric acetate and phorbol ester.,miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.,PTM:N- and O-glycosylated.,PTM:Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 3 fibronectin type-II domains.,similarity:Contains 4 hemopexin-like domains.,subunit:Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.,tissue specificity:Produced by normal alveolar macrophages and granulocytes.

應(yīng)用：WB;IHC;IF;IP;ELISA
稀釋比例： IHC 1:200-1000,WB 1:500-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

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