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50μL/100μL

Catalog No : AR1004

Reactivity : Human;Mouse;Rat;

Applications : WB;IHC;IF;IP;ELISA

Target : NLRP3

Fields : >>Necroptosis;>>NOD-like receptor signaling pathway;>>C-type lectin receptor signaling pathway;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Yersinia infection;>>Influenza A;>>Coronavirus disease - COVID-19;>>Lipid and atherosclerosis

Gene Name : NLRP3

Protein Name : NACHT LRR and PYD domains-containing protein 3

Human Gene Id : 114548

Human Swiss Prot No : Q96P20

Mouse Swiss Prot No : Q8R4B8

Specificity : endogenous Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : IHC 1:200-1000,WB 1:500-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : -20°C

Observed Band : 115kD

Cell Pathway : NOD-like receptor;

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotidebinding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NFkappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatalonset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are s

應(yīng)用：WB;IHC;IF;IP;ELISA
稀釋比例： IHC 1:200-1000,WB 1:500-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

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