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50μL/100μL

Catalog No :AR1013

Reactivity : Human; Mouse; Rat;

Applications : WB;IP;ELISA

Target : gp91-phox

Fields : >>HIF-1 signaling pathway;>>Phagosome;>>Ferroptosis;>>Necroptosis;>>Neutrophil extracellular trap formation;>>NOD-like receptor signaling pathway;>>Leukocyte transendothelial migration;>>AGE-RAGE signaling pathway in diabetic complications;>>Alzheimer disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Leishmaniasis;>>Coronavirus disease COVID-19;>>Diabetic cardiomyopathy;>>Lipid and atherosclerosis

Gene Name : CYBB

Protein Name : Cytochrome b-245 heavy chain

Human Gene Id : 1536

Human Swiss Prot No :P04839

Mouse Swiss Prot No :Q61093

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : WB 1:1000-5000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : -20°C

Molecularweight : 65kD

Observed Band : 65kD

Cell Pathway : Leukocyte transendothelial migration;

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

應(yīng)用：WB;IP;ELISA
稀釋比例：WB 1:1000-5000,ELISA 1:5000-20000,IP 1:50-200

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