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50μL/100μL

Catalog No :AR1028

Reactivity : Human;

Applications : WB;IF;IP;ELISA

Target : p14ARF

Gene Name : CDKN2A

Protein Name : Cyclin-dependent kinase inhibitor 2A isoform 4

Human Gene Id : 1029

Human Swiss Prot No :Q8N726

Mouse Swiss Prot No :Q64364

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : -20°C

Molecularweight : 14kD

Observed Band : 16kD

Cell Pathway : Stem cell pathway; Cell Cycle

CDKN2A generates several transcript variants which differ in their first exons. At  least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by CDKN2A, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. CDKN2A is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

應(yīng)用：WB;IF;IP;ELISA
稀釋比例: WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

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