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50μL/100μL

Catalog No : AR1029

Reactivity : Human;

Applications : WB;IHC;IF;IP;ELISA

Target : FGF Receptor 1

Fields : >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Adherens junction;>>Signaling pathways regulating pluripotency of stem cells;>>Thermogenesis;>>Regulation of actin cytoskeleton;>>Parathyroid hormone synthesis, secretion and action;>>Pathways in cancer;>>Proteoglycans in cancer;>>Prostate cancer;>>Melanoma;>>Breast cancer;>>Central carbon metabolism in cancer

Gene Name : FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR

Protein Name : Fibroblast growth factor receptor 1

Human Gene Id : 2260

Human Swiss Prot No :P11362

Mouse Gene Id : 14182

Mouse Swiss Prot No :P16092

Rat Gene Id : 79114

Rat Swiss Prot No : Q04589

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : IHC 1:100-200,WB 1:500-2000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : -20°C

Molecularweight : 91kD

Observed Band : 145kD

Cell Pathway : MAPK_ERK_Growth;MAPK_G_Protein;Adherens_Junction;Regulates Actin and Cytoskeleton;Pathways in cancer;Prostate cancer;Melanoma

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome

應(yīng)用：WB;IHC;IF;IP;ELISA
稀釋比例： IHC 1:100-200,WB 1:500-2000,IF 1:200-1000,ELISA 1:5000-20000,IP
1:50-200

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