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50μL/100μL

Catalog No : AR1030

Reactivity : Human; Rat;

Applications : WB;IHC;IF;IP;ELISA

Target : SIRT1

Fields : >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>FoxO signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Cellular senescence;>>Glucagon signaling pathway;>>Alcoholic liver disease;>>Amphetamine addiction;>>MicroRNAs in cancer

Gene Name : SIRT1

Protein Name : NAD-dependent protein deacetylase sirtuin-1

Human Gene Id : 23411

Human Swiss Prot No :Q96EB6

Mouse Gene Id : 93759

Mouse Swiss Prot No :Q923E4

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution :IHC 1:100-200,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : -20°C

Molecularweight : 81kD

Observed Band : 130kD

Cell Pathway : Protein_Acetylation

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

應(yīng)用：WB;IHC;IF;IP;ELISA
稀釋比例： IHC 1:100-200,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP
1:50-200

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