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50μL/100μL

Catalog No : AR1041

Reactivity : Human;

Applications : WB;IHC;IF;IP;ELISA

Target : RIPK1

Fields : >>NF-kappa B signaling pathway;>>Apoptosis;>>Necroptosis;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>TNF signaling pathway;>>Alcoholic liver disease;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Hepatitis C;>>Human cytomegalovirus infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection

Gene Name : RIPK1 RIP RIP1

Protein Name : Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) (Serine/threonine-protein kinase RIP)

Human Gene Id : 8737

Human Swiss Prot No :Q13546

Mouse Swiss Prot No :Q60855

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : IHC 1:200-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : -20°C

Molecularweight : 76kD

Observed Band : 76kD

Cell Pathway Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Toll_Like;RI G-I-like receptor;Cytosolic DNA-sensing pathway

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1.,

應(yīng)用：WB;IHC;IF;IP;ELISA
稀釋比例： IHC 1:200-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP
1:50-200

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