商品詳情
【產(chǎn)品包裝】
50μL/100μL
【產(chǎn)品特點(diǎn)】
Catalog No : AR1049
Reactivity : Human; Mouse; Rat;
Applications : WB;IHC;IF;IP;ELISA
Target : Cyclin E1
Fields :>>Cell cycle;>>Oocyte meiosis;>>p53 signaling pathway;>>PI3K-Akt signaling pathway;>>Cellular senescence;>>Cushing syndrome;>>Hepatitis B;>>Measles;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Viral carcinogenesis;>>MicroRNAs in cancer;>>Prostate cancer;>>Small cell lung cancer;>>Gastric cancer
Gene Name : CCNE1
Protein Name : G1/S-specific cyclin-E1
Human Gene Id : 898
Human Swiss Prot No :P24864
Mouse Gene Id : 12447
Mouse Swiss Prot No :Q61457
Rat Swiss Prot No : P39949
Specificity : endogenous
Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source : Monoclonal, rabbit, IgG, Kappa
Dilution : IHC 1:400-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200
Purification : Protein A
Storage Stability : -20°C
Molecularweight : 47kD
Observed Band : 47kD
Cell Pathway : Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;p53;Pathways in cancer;Prostate cancer;Small cell lung cancer
【產(chǎn)品介紹】
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in
【使用方法】
應(yīng)用: WB;IHC;IF;IP;ELISA
稀釋比例: IHC 1:400-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP
1:50-200
【注意事項(xiàng)】
避免反復(fù)凍融