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50μL/100μL

Catalog No : AR1051

Reactivity : Human; Mouse; Rat;

Applications : WB;IF;IP;ELISA

Target : ATF6A

Fields : >>Protein processing in endoplasmic reticulum;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases;>>Lipid and atherosclerosis

Gene Name : ATF6

Protein Name : ATF6A

Human Gene Id : 22926

Human Swiss Prot No :P18850

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

Purification : Protein A

Storage Stability : -20°C

Molecularweight : 75kD

Observed Band : 100kD

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress.  Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

應(yīng)用： WB;IF;IP;ELISA
稀釋比例： WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

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