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50μL/100μL

Catalog No : AR1086

Reactivity : Human;Rat;

Applications : WB;IHC;IF;IP;ELISA

Target : P21

Gene Name : CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1

Protein Name : p21

Human Gene Id : 1026

Human Swiss Prot No :P38936

Mouse Gene Id : 12575

Mouse Swiss Prot No :P39689

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : IHC 1:100-1:200,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

Purification : Protein A

Storage Stability : -20°C

Molecularweight : 18kD

Observed Band : 18kD

function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.

應(yīng)用： WB;IHC;IF;IP;ELISA
稀釋比例： IHC 1:100-1:200,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

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