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50μL/100μL

Catalog No : AR1091

Reactivity : Human;Mouse;Rat;

Applications : WB;IHC;IF;IP;ELISA

Target : Calregulin

Fields : >>Protein processing in endoplasmic reticulum;>>Phagosome;>>Antigen processing and presentation;>>Chagas disease;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection

Gene Name : CALR

Protein Name : Calreticulin

Human Gene Id : 811

Human Swiss Prot No :P27797

Mouse Gene Id : 12317

Mouse Swiss Prot No :P14211

Rat Gene Id : 64202

Rat Swiss Prot No : P18418

Specificity : endogenous

Formulation : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source : Monoclonal, rabbit, IgG, Kappa

Dilution : IHC 1:200-1:1000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200

Purification : Protein A

Storage Stability : -20°C

Molecularweight : 48kD

Observed Band : 55kD

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its

應(yīng)用： WB;IHC;IF;IP;ELISA
稀釋比例： IHC 1:200-1:1000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA
1:5000-1:20000,IP 1:50-1:200

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