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Catalog No :AR1144

Reactivity :

Human; Mouse; Rat;

Applications :

WB;IF;IP;ELISA

Gene Name :

>>Mitophagy - animal;>>Autophagy - animal;>>Protein processing in endoplasmic reticulum;>>Apoptosis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Hepatitis C;>>Measles;>>Herpes simplex virus 1 infection;>>Lipid and atherosclerosis

Protein Name :

EIF2AK3

Sequence :

Eukaryotic translation initiation factor 2-alpha kinase 3

Human Gene Id :

9451

Human Swiss Prot

No :

Q9NZJ5

Mouse Swiss Prot

No :

Q9Z2B5

Rat Gene Id :

29702

Rat Swiss Prot No : Q9Z1Z1

Specificity :

endogenous

Formulation :

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source :

Monoclonal, rabbit, IgG, Kappa

Dilution :

WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

Purification :

Protein A

Storage Stability :

-15°C to -25°C/1 year(Do not lower than -25°C)

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]